Siever L J, Insel T R, Jimerson D C, Lake C R, Uhde T W, Aloi J, Murphy D L
Br J Psychiatry. 1983 Feb;142:184-7. doi: 10.1192/bjp.142.2.184.
We have observed a lesser growth hormone response to intravenous clonidine administration in nine obsessive-compulsive disorder patients meeting research diagnostic criteria than in nine matched controls. The obsessive-compulsive disorder patients had higher plasma free 3-methoxy-4-hydroxyphenylglycol and plasma norepinephrine levels before clonidine than the controls. As blunted growth hormone responses to clonidine are also characteristic of affective disorder patients, these results support other observations of a psychobiologic affinity between these two groups and are also compatible with an association between increased presynaptic noradrenergic activity and decreased post-synaptic receptor responsiveness.
我们观察到，9名符合研究诊断标准的强迫症患者对静脉注射可乐定的生长激素反应，低于9名匹配的对照组。在注射可乐定之前，强迫症患者的血浆游离3-甲氧基-4-羟基苯乙二醇和血浆去甲肾上腺素水平高于对照组。由于对可乐定的生长激素反应迟钝也是情感障碍患者的特征，这些结果支持了这两组之间存在心理生物学关联的其他观察结果，也与突触前去甲肾上腺素能活性增加和突触后受体反应性降低之间的关联相一致。
