原发性情感障碍及其他三环类药物反应性疾病中的生物学改变。

Biological alterations in the primary affective disorders and other tricyclic-responsive disorders.

作者信息

Siever L J, Uhde T W, Insel T R, Kaye W H, Jimerson D C, Lake C R, Kafka M, Targum S, Murphy D L

出版信息

Prog Neuropsychopharmacol Biol Psychiatry. 1985;9(1):15-24. doi: 10.1016/0278-5846(85)90175-7.

Abstract

Noradrenergic function was studied in patients with primary affective disorder and other tricyclic-responsive disorders including obsessive-compulsive disorder, anorexia nervosa and panic attack/agoraphobia in medication-free states. Pre-synaptic noradrenergic activity was assessed by assaying plasma concentrations of norepinephrine (NE) and its metabolite 3-methoxy,4-hydroxyphenylglycol (MHPG). Noradrenergic receptor responsiveness was evaluated by measuring plasma growth hormone (GH), MHPG, and NE responses to clonidine. Binding of tritiated dihydroergocriptine (3H-DHE) and biochemical responsiveness of alpha 2-adrenergic receptors were measured in platelet preparations. These studies suggest that noradrenergic activity may be altered in several tricyclic-responsive disorders and are consistent with the possibility that tricyclic antidepressants may serve to stabilize a dysregulated noradrenergic system in patients from several diagnostic categories.

摘要

在无药物状态下，对原发性情感障碍患者以及其他三环类药物反应性疾病患者（包括强迫症、神经性厌食症和惊恐发作/广场恐惧症）的去甲肾上腺素能功能进行了研究。通过测定血浆去甲肾上腺素（NE）及其代谢产物3-甲氧基-4-羟基苯乙二醇（MHPG）的浓度来评估突触前去甲肾上腺素能活性。通过测量血浆生长激素（GH）、MHPG和NE对可乐定的反应来评估去甲肾上腺素能受体反应性。在血小板制剂中测量氚标记双氢麦角隐亭（3H-DHE）的结合以及α2-肾上腺素能受体的生化反应性。这些研究表明，在几种三环类药物反应性疾病中，去甲肾上腺素能活性可能会发生改变，这与三环类抗抑郁药可能有助于稳定来自几个诊断类别的患者中失调的去甲肾上腺素能系统的可能性是一致的。