Doll R, Kinlen L
Lancet. 1977 Jun 18;1(8025):1300-2. doi: 10.1016/s0140-6736(77)91332-0.
Authoritative statements that fluoridation of public water supplies is not associated with any increase in cancer have been challenged on the basis of data which, it is claimed, show that cancer mortality in the United States rose more sharply in cities with fluoridated water than in those without. However, during the period of study (1950-70) the population structures of these cities changed substantially. When account is taken of age, sex, and ethnic group the ratio between observed cancer mortality and expected cancer mortality fell slightly in the cities with fluoridated water and did not change in the non-fluoridated cities.
关于公共供水氟化与癌症发病率上升并无关联的权威声明受到了质疑，其所依据的数据表明，美国饮用含氟水的城市癌症死亡率比未饮用含氟水的城市上升幅度更大。然而，在研究期间（1950 - 1970年），这些城市的人口结构发生了显著变化。考虑到年龄、性别和种族因素后，饮用含氟水城市的实际癌症死亡率与预期癌症死亡率之比略有下降，而未饮用含氟水的城市这一比例则没有变化。
