de Paepe M, Lameire N, Belpaire F, Bogaert M
Clin Nephrol. 1983 Mar;19(3):107-9.
The peritoneal pharmacokinetics of gentamicin were investigated in patients on continuous ambulatory peritoneal dialysis. Gentamicin was added to the dialyzate, and gentamicin concentrations were measured repeatedly in serum and dialyzate. After administration of a single dose of gentamicin, equilibrium between serum and dialyzate levels is achieved within 24 hours; dialyzate levels of gentamicin are lower and mass transfer coefficients higher in patients with peritonitis. With chronic intraperitoneal gentamicin treatment for peritonitis, steady state serum levels around 4 to 5 mg/l are achieved and otovestibular toxicity should be feared.
在持续非卧床腹膜透析患者中研究了庆大霉素的腹膜药代动力学。将庆大霉素加入透析液中，并反复测定血清和透析液中的庆大霉素浓度。单次给予庆大霉素后，血清和透析液水平在24小时内达到平衡；腹膜炎患者的透析液中庆大霉素水平较低，而传质系数较高。对于腹膜炎采用慢性腹腔内庆大霉素治疗时，血清稳态水平可达4至5mg/l左右，应警惕耳前庭毒性。
