Richey G D, Schleupner C J
Antimicrob Agents Chemother. 1981 Feb;19(2):312-5. doi: 10.1128/AAC.19.2.312.
Simultaneous peritoneal fluid and serum gentamicin assays were performed at 1- or 4-h intervals after the intravenous administration of gentamicin (3 to 5 mg/kg per day) during nine episodes of spontaneous bacterial peritonitis in cirrhotic patients. Mean peritoneal fluid levels were 4.2 micrograms/ml, whereas simultaneous mean serum levels were 6.1 micrograms/ml (mean percent diffusion into ascites of 67.8%). Three additional patients with uninflamed ascites demonstrated lower levels of diffusion. Regression analysis revealed a positive correlation between simultaneous serum and peritoneal fluid levels. We conclude that diffusion of gentamicin from serum into peritoneal fluid during spontaneous peritonitis is therapeutically adequate if sufficient serum levels are maintained.
在肝硬化患者发生的9次自发性细菌性腹膜炎发作期间，静脉注射庆大霉素（每天3至5毫克/千克）后，每隔1或4小时同时进行腹膜液和血清庆大霉素检测。腹膜液平均水平为4.2微克/毫升，而同时的血清平均水平为6.1微克/毫升（扩散至腹水的平均百分比为67.8%）。另外3例腹水未发炎的患者显示出较低的扩散水平。回归分析显示血清和腹膜液水平之间呈正相关。我们得出结论，如果维持足够的血清水平，在自发性腹膜炎期间庆大霉素从血清扩散至腹膜液在治疗上是足够的。
