重复剂量的17β-雌二醇对雄性欧洲比目鱼（Platichtys flesus L.）血清葡萄糖和脂质、肝糖原及肝脏中一些碳水化合物代谢酶影响的时间进程研究。

A time course study of the effect of repetitive doses of estradiol-17 beta on serum glucose and lipids, liver glycogen and some carbohydrate metabolizing enzymes in liver of male flounder (Platichtys flesus L.).

Petersen I M, Sand O, Korsgaard B

Comp Biochem Physiol B. 1983;74(3):459-66. doi: 10.1016/0305-0491(83)90211-0.

Abstract

Repeated treatment of male flounder with 5 and 100 microgram doses of estradiol-17 beta increases the level of phospholipid, triglyceride, free fatty acids and total lipid in serum as a function of time and dose, during a period of 17 days. 2. The glucose level in serum is increased and decreased respectively by doses of 5 and 100 micrograms. 3. Five and 100 microgram doses decrease the level of glycogen in liver. 4. Five microgram doses do not affect the activity of the measured enzymes considerably, with the exception of phosphorylase a. 5. One hundred microgram doses increase the activity of glucose-6-phosphate dehydrogenase after 11 days. 6. One hundred microgram doses increase the activity of pyruvate kinase continuously during the experimental period and decrease phosphorylase a and glucose-6-phosphatase activity.

摘要

在17天的时间里，用5微克和100微克剂量的17β-雌二醇反复处理雄性比目鱼，血清中的磷脂、甘油三酯、游离脂肪酸和总脂质水平会随时间和剂量增加。2. 5微克和100微克剂量分别会使血清中的葡萄糖水平升高和降低。3. 5微克和100微克剂量会降低肝脏中的糖原水平。4. 5微克剂量对所测酶的活性影响不大，磷酸化酶a除外。5. 100微克剂量在11天后会增加葡萄糖-6-磷酸脱氢酶的活性。6. 在实验期间，100微克剂量会持续增加丙酮酸激酶的活性，并降低磷酸化酶a和葡萄糖-6-磷酸酶的活性。