Vita G, Dattola R, Girlanda P, Oteri G, Lo Presti F, Messina C
Exp Neurol. 1983 May;80(2):279-87. doi: 10.1016/0014-4886(83)90282-0.
The ability of an association of three steroid hormones to influence the reinnervation process and the trophism of rabbit muscles denervated by crush of the sciatic nerve was investigated. The beginning of reinnervation was established with electromyographic recordings from the tibialis anterior muscle. The distance from the site of crushing to the point where the motor nerve enters the tibialis anterior muscle was then measured in each animal, and the nerve regeneration velocity (mm/day) was calculated: a slightly but significantly higher (P less than 0.001) mean value was found in treated animals compared with untreated ones. When soleus and extensor digitorum longus (EDL) muscles were histochemically examined 50 days after lesion, a larger mean diameter of type 2c fibers was found in treated than in untreated animals, pointing out a possible useful effect of the treatment. On the contrary, the size reduction of EDL type 2b fibers was more pronounced in treated rabbits, indicating a catabolic influence of the drugs on this fiber type.
研究了三种甾体激素联合作用对兔坐骨神经挤压所致失神经肌肉的再支配过程和营养状况的影响。通过记录胫骨前肌的肌电图来确定再支配的开始。然后测量每只动物从神经挤压部位到运动神经进入胫骨前肌点的距离，并计算神经再生速度（毫米/天）：与未治疗的动物相比，治疗组动物的平均再生速度略高但具有显著差异（P<0.001）。在损伤后50天对比目鱼肌和趾长伸肌（EDL）进行组织化学检查时，发现治疗组动物的2c型纤维平均直径大于未治疗组，表明该治疗可能具有有益作用。相反，治疗组兔的EDL 2b型纤维尺寸减小更为明显，表明这些药物对该纤维类型具有分解代谢作用。
