Rassat J, Robenek H, Themann H
Exp Pathol. 1983;23(1):35-44. doi: 10.1016/s0232-1513(83)80039-5.
Ultrastructural changes in the tubular epithelium of the rat kidney following a large dose of estrogen (300 micrograms per week for 20 weeks) were studied by means of electron microscopy. The ultrastructural changes in estrogen-treated rats were confined to the proximal tubule. The changes consisted of intracytoplasmic vacuoles and dilatation of the intracellular space between adjacent tubule cells. The cisternae of the endoplasmic reticulum exhibited some degree of vesiculation characterized by club-like formations. In addition, large masses of collagen could be observed within the peritubular capillaries. In contrast to the controls the tubular cells of estrogen-treated rats exhibited large areas or granules with dense inclusions and membranous, filamentous material in a process of being transformed into an autolysosome and residual body. The results are discussed in the light of those of other authors.
通过电子显微镜研究了大鼠肾脏在大剂量雌激素（每周300微克，持续20周）作用下肾小管上皮的超微结构变化。雌激素处理组大鼠的超微结构变化局限于近端小管。变化包括胞浆内空泡以及相邻小管细胞间细胞内空间的扩张。内质网池呈现出一定程度的囊泡化，其特征为棒状结构。此外，在肾小管周围毛细血管内可观察到大量胶原。与对照组相比，雌激素处理组大鼠的肾小管细胞表现出大面积或含有致密内含物的颗粒，以及正转化为自溶酶体和残余小体的膜性、丝状物质。结合其他作者的研究结果对这些结果进行了讨论。
