链脲佐菌素诱导的糖尿病会导致脂肪细胞脂解作用对胰高血糖素的反应性增强。
Streptozotocin diabetes results in increased responsiveness of adipocyte lipolysis to glucagon.
作者信息
Chatzipanteli K, Saggerson D
出版信息
FEBS Lett. 1983 May 2;155(1):135-8. doi: 10.1016/0014-5793(83)80225-7.
PMID:6840281
Abstract
Adipocytes from streptozotocin-diabetic rats are approximately 50-times more sensitive to the lipolytic action of glucagon. This change is only perceived in the presence of a small quantity of adenosine deaminase which itself has little effect on basal lipolysis. Insulin treatment restores glucagon sensitivity to normal.
摘要
链脲佐菌素诱导的糖尿病大鼠的脂肪细胞对胰高血糖素的脂解作用的敏感性大约高50倍。这种变化只有在存在少量腺苷脱氨酶的情况下才会显现，而腺苷脱氨酶本身对基础脂解作用影响很小。胰岛素治疗可使胰高血糖素敏感性恢复正常。
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