饥饿大鼠脂肪细胞对胰高血糖素和腺苷脱氨酶的脂解反应改变。
Altered lipolytic response to glucagon and adenosine deaminase in adipocytes from starved rats.
作者信息
Honnor R C, Saggerson E D
出版信息
Biochem J. 1980 Jun 15;188(3):757-61. doi: 10.1042/bj1880757.
Abstract
- Adipocytes isolated from epididymal adipose tissue of fed or 24 h-starved rats were incubated with a range of glucagon concentrations in the presence and absence of adenosine deaminase (4 munits/ml). 2. With adenosine deaminase present, the lipolytic response to low concentrations of glucagon (1-6 ng/ml) was considerably enhanced in cells from starved rats. 3. The effect of adenosine deaminase on basal lipolysis was altered after starvation. 4. D-3-Hydroxybutyrate (5 mM) decreased the sensitivity of lipolysis to glucagon. 5. The possible involvement of glucagon-stimulated lipolysis in the regulation of ketogenesis is briefly discussed.
摘要
- 将从喂食或饥饿24小时大鼠的附睾脂肪组织中分离出的脂肪细胞，在存在和不存在腺苷脱氨酶（4单位/毫升）的情况下，与一系列胰高血糖素浓度一起孵育。2. 存在腺苷脱氨酶时，饥饿大鼠细胞对低浓度胰高血糖素（1-6纳克/毫升）的脂解反应显著增强。3. 饥饿后，腺苷脱氨酶对基础脂解的作用发生改变。4. D-3-羟基丁酸（5毫摩尔）降低了脂解对胰高血糖素的敏感性。5. 简要讨论了胰高血糖素刺激的脂解在酮体生成调节中的可能作用。
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