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等效孔隙模型:囊泡与通道

Equivalent pore modeling: vesicles and channels.

作者信息

Taylor A E, Granger D N

出版信息

Fed Proc. 1983 May 15;42(8):2440-5.

PMID:6840295
Abstract

The methods used to estimate equivalent pores in capillary walls using lymph protein flux analyses are presented. The capillary walls in several different organs can be described by a two-pore model that incorporates pores of radii 50-80 and 200-250 A. The most likely ultrastructural correlates of these physiological pores appear to be the transendothelial channels. In addition, the positive charge associated with endogenous protein transport in intestinal and lung capillaries may reflect the positive charge located on the inner walls of the transendothelial channel.

摘要

介绍了利用淋巴蛋白通量分析估算毛细血管壁等效孔的方法。几种不同器官的毛细血管壁可用双孔模型来描述,该模型包含半径为50 - 80埃和200 - 250埃的孔。这些生理孔最可能的超微结构对应物似乎是跨内皮通道。此外,肠道和肺毛细血管中与内源性蛋白质转运相关的正电荷可能反映了跨内皮通道内壁上的正电荷。

相似文献

1
Equivalent pore modeling: vesicles and channels.等效孔隙模型:囊泡与通道
Fed Proc. 1983 May 15;42(8):2440-5.
2
Physiological studies of macromolecular transport across capillary walls. Studies on continuous capillaries in rat skeletal muscle.大分子跨毛细血管壁转运的生理学研究。大鼠骨骼肌连续毛细血管的研究。
Acta Physiol Scand Suppl. 1986;553:1-40.
3
Structural aspects of the permeability of the microvascular endothelium.微血管内皮细胞通透性的结构方面
Acta Physiol Scand Suppl. 1979;463:11-32.
4
[Ultrastructural mechanisms of transendothelial transport in blood vessels].[血管内皮细胞跨膜转运的超微结构机制]
Eksp Med Morfol. 1980;19(4):189-96.
5
Proteins and vesicular transport in capillary endothelium.毛细血管内皮中的蛋白质与囊泡运输
Fed Proc. 1983 May 15;42(8):2419-24.
6
Relation of capillary morphology to transport of fluid and large molecules: a review.
Acta Physiol Scand Suppl. 1979;463:81-91.
7
Transport of macromolecules through microvascular walls.大分子通过微血管壁的转运。
Cardiovasc Res. 1996 Oct;32(4):644-53.
8
Morphological and cytochemical aspects of capillary permeability.
Microsc Res Tech. 2002 Jun 1;57(5):327-49. doi: 10.1002/jemt.10088.
9
Vesicular transport in capillary endothelium: does it occur?毛细血管内皮中的囊泡运输:它会发生吗?
Fed Proc. 1983 May 15;42(8):2425-30.
10
Ultrastructural studies define soluble macromolecular, particulate, and cellular transendothelial cell pathways in venules, lymphatic vessels, and tumor-associated microvessels in man and animals.超微结构研究确定了人和动物的小静脉、淋巴管及肿瘤相关微血管中可溶性大分子、颗粒及细胞的跨内皮细胞途径。
Microsc Res Tech. 2002 Jun 1;57(5):289-326. doi: 10.1002/jemt.10087.

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J Physiol. 1984 Aug;353:317-37. doi: 10.1113/jphysiol.1984.sp015338.
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Ann Biomed Eng. 1987;15(2):157-72. doi: 10.1007/BF02364051.
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J Pharmacokinet Biopharm. 1988 Apr;16(2):129-49. doi: 10.1007/BF01062256.