Saijo N, Ozaki A, Beppu Y, Irimajiri N, Shibuya M, Shimizu E, Takizawa T, Taniguchi T, Hoshi A
Gan. 1983 Feb;74(1):137-42.
The in vivo and in vitro effects of Nocardia rubra cell wall skeleton (N-CWS) on natural killer (NK) activity of spleen and peritoneal lymphocytes of C57BL/6 mice were studied. The NK activity of spleen and peritoneal lymphocytes against YAC-1 lymphoma cells and cultured B-16 melanoma cells peaked at 3 days after intraperitoneal or intravenous administration of N-CWS, and returned to the normal value 7 days later. The NK activity of spleen lymphocytes was augmented by in vitro incubation with N-CWS. The appropriate concentration of N-CWS for the in vitro stimulation of NK activity in spleen lymphocytes was 2-5 micrograms/ml.
研究了红色诺卡氏菌细胞壁骨架（N-CWS）对C57BL/6小鼠脾脏和腹腔淋巴细胞自然杀伤（NK）活性的体内和体外作用。脾脏和腹腔淋巴细胞对YAC-1淋巴瘤细胞和培养的B-16黑色素瘤细胞的NK活性在腹腔或静脉注射N-CWS后3天达到峰值，并在7天后恢复到正常值。脾脏淋巴细胞的NK活性通过与N-CWS体外孵育而增强。体外刺激脾脏淋巴细胞NK活性的N-CWS适宜浓度为2-5微克/毫升。
