Hansson T, Rafter J
Gen Comp Endocrinol. 1983 Mar;49(3):490-5. doi: 10.1016/0016-6480(83)90213-7.
The metabolism of [4-14C]estradiol-17 beta by liver microsomes from, Salmo gairdneri, was studied in vitro. The following metabolites were identified by gas chromatography--mass spectrometry: estrone, estra-1,3,5(10)-triene-3,16 beta,17 beta-triol, and estra-1,3,5(10)-triene-3,7 alpha,17 beta-triol. The presence of additional polar metabolites hydroxylated at positions 6 alpha and 6 beta was indicated. The formation of the hydroxylated metabolites was inhibited by CO indicating the participation of cytochrome P-450-dependent enzymes.
对来自虹鳟鱼的肝微粒体在体外对[4-¹⁴C]雌二醇-17β的代谢进行了研究。通过气相色谱-质谱法鉴定出以下代谢物：雌酮、estra-1,3,5(10)-三烯-3,16β,17β-三醇和estra-1,3,5(10)-三烯-3,7α,17β-三醇。表明存在在6α和6β位羟基化的其他极性代谢物。羟基化代谢物的形成受到一氧化碳的抑制，这表明细胞色素P-450依赖性酶参与其中。
