雌性豚鼠肝微粒体对雌酮、17β-雌二醇及其3-硫酸盐的代谢
The metabolism of estrone and estradiol-17beta and their 3-sulfates by female guinea pig liver microsomes.
作者信息
Harvey P R, Hobkirk R
出版信息
Steroids. 1977 Jul;30(1):115-28. doi: 10.1016/0039-128x(77)90142-8.
The metabolism, by female guinea pig liver microsomes of estrogen 3-sulfates (estrone-3-sulfate and 17beta-estradiol-3-sulfate) was compared to that of the unconjugated estrogens, estrone and estradiol-17beta. Metabolites identified indicated that 16beta-hydroxylated products (16beta judrpxuestrpme amd 16 epiestriol) arose mainly from the free estrogens while 16alpha-hydroxy steroid sulfates (16alpha hydroxyestrone-3-sulfate and estriol-3-sulfates and estriol-3-sulfate) were predominantly formed from the sulfated estrogens. These results show that the sulfate moiety at position 3 of the steroids directs 16-hydroxylation from the beta to the alpha configuration.
将雌性豚鼠肝微粒体对雌激素3 - 硫酸盐（硫酸雌酮和17β - 雌二醇 - 3 - 硫酸盐）的代谢与未结合雌激素（雌酮和17β - 雌二醇）的代谢进行了比较。鉴定出的代谢产物表明，16β - 羟基化产物（16β - 羟基雌酮和16 - 表雌三醇）主要来自游离雌激素，而16α - 羟基类固醇硫酸盐（16α - 羟基硫酸雌酮和硫酸雌三醇）主要由硫酸化雌激素形成。这些结果表明，类固醇3位的硫酸基团将16 - 羟基化从β构型导向α构型。
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