α地中海贫血基因的选择。
Selection for the alpha-thalassemia genes.
作者信息
Yokoyama S
出版信息
Genetics. 1983 Jan;103(1):143-8. doi: 10.1093/genetics/103.1.143.
Abstract
Extremely high incidences of single and double deletions of alpha-globin genes are known among Asian populations. To study possible mechanisms for the maintenance of such deletions, mathematical analyses have been conducted. It has been shown that a stable polymorphism can be achieved easily through heterozygote advantage using deterministic models. The results strongly suggest that high incidences of single and double deletion of alpha-globin genes among Asian populations are maintained by some type of heterozygote advantage.
摘要
在亚洲人群中，已知α-珠蛋白基因单缺失和双缺失的发生率极高。为了研究维持此类缺失的可能机制，已进行了数学分析。结果表明，使用确定性模型，通过杂合子优势可轻松实现稳定的多态性。这些结果有力地表明，亚洲人群中α-珠蛋白基因单缺失和双缺失的高发生率是由某种类型的杂合子优势维持的。
相似文献
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Selection for the alpha-thalassemia genes.α地中海贫血基因的选择。
Genetics. 1983 Jan;103(1):143-8. doi: 10.1093/genetics/103.1.143.
2
Equilibrium frequencies of alpha-globin genes.α-珠蛋白基因的平衡频率。
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3
Two different molecular organizations account for the single alpha-globin gene of the alpha-thalassemia-2 genotype.两种不同的分子组织构成了α地中海贫血-2基因型的单个α珠蛋白基因。
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4
Alpha-thalassemia in blacks is due to gene deletion.黑人中的α地中海贫血是由基因缺失引起的。
Am J Hum Genet. 1979 Sep;31(5):569-73.
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Is the doubly deleted alpha-thalassemia gene a "fugitive" allele?双重缺失的α地中海贫血基因是一个“逃逸”等位基因吗？
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An alpha-globin gene initiation codon mutation in a black family with HbH disease.一个患有血红蛋白H病的黑人家庭中的α-珠蛋白基因起始密码子突变。
Blood. 1987 Sep;70(3):729-32.
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A beta-thalassemia mutant caused by a 300-bp deletion in the human beta-globin gene.一种由人类β-珠蛋白基因中300个碱基对缺失引起的β-地中海贫血突变体。
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Molecular genetics of alpha thalassemia.α地中海贫血的分子遗传学
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本文引用的文献
1
Genetic variation in small multigene families.小多基因家族中的遗传变异。
Genet Res. 1981 Apr;37(2):133-49. doi: 10.1017/s0016672300020115.
2
Is the doubly deleted alpha-thalassemia gene a "fugitive" allele?双重缺失的α地中海贫血基因是一个“逃逸”等位基因吗？
Am J Hum Genet. 1981 Mar;33(2):215-26.
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