一名老年女性肝脏的原发性恶性间叶性肿瘤。

Primary malignant mesenchymal tumour of the liver in an elderly female.

作者信息

Ellis I O, Cotton R E

出版信息

Histopathology. 1983 Jan;7(1):113-21. doi: 10.1111/j.1365-2559.1983.tb02221.x.

DOI:10.1111/j.1365-2559.1983.tb02221.x

Abstract

A case of primary malignant mesenchymal tumour of the liver occurring in an 86-year-old woman is described. This very uncommon tumour has previously only been described in children and young adults, the previous oldest being 28 years of age. The tumour was large, rapidly growing though well circumscribed and extensively necrotic. Microscopically it was mostly composed of spindle cell sarcoma without differentiating features. Epithelial lined ductules were seen throughout the tumour and degenerate hepatocytes were enveloped in the tumour peripherally. Intracytoplasmic and extracellular PAS-positive, diastase-resistant bodies were present, some showing positive staining for alpha-I-antitrypsin. The tumour is compared with previous reports and its differential diagnosis and nomenclature discussed.

摘要

本文描述了一例发生在一名86岁女性身上的原发性肝脏恶性间充质肿瘤。这种非常罕见的肿瘤此前仅在儿童和年轻人中被描述过，之前报道的患者年龄最大为28岁。肿瘤体积较大，生长迅速，边界清晰，但有广泛坏死。显微镜下，它主要由无分化特征的梭形细胞肉瘤组成。肿瘤内可见内衬上皮的小导管，肿瘤周边有退变的肝细胞被包裹其中。胞浆内和胞外存在PAS阳性、淀粉酶抵抗性物质，部分对α-1抗胰蛋白酶呈阳性染色。将该肿瘤与既往报道进行了比较，并讨论了其鉴别诊断和命名。