重症肌无力的免疫学

Immunology of myasthenia gravis.

作者信息

Biesecker G, Koffler D

出版信息

Hum Pathol. 1983 May;14(5):419-23. doi: 10.1016/s0046-8177(83)80286-x.

Abstract

Anti-acetylcholine-receptor antibody is demonstrable in more than 90 per cent of patients with myasthenia gravis. Serum antibody titers do not show a direct correlation with disease severity, although in certain patients antibody levels increase in association with disease activity. Impairment of neuromuscular transmission results from the loss of junctional receptors, either as a result of receptor internalization or destruction of junctional folds containing the acetylcholine receptor. Myasthenia gravis manifests immunologic, genetic, and clinical similarities to rheumatic syndromes, suggesting a generic immune dysfunction common to these disorders.

摘要

90%以上的重症肌无力患者体内可检测到抗乙酰胆碱受体抗体。血清抗体滴度与疾病严重程度无直接相关性，不过在某些患者中，抗体水平会随疾病活动而升高。神经肌肉传递受损是由于接头处受体丧失，这可能是受体内化或含有乙酰胆碱受体的接头皱襞遭到破坏所致。重症肌无力在免疫、遗传和临床方面与风湿综合征存在相似之处，提示这些疾病存在共同的一般免疫功能障碍。