Saiki I, Tokushima Y, Nishimura K, Yamamura Y, Azuma I
Infect Immun. 1983 May;40(2):622-8. doi: 10.1128/iai.40.2.622-628.1983.
The effect of 6-O-QS-10-N-acetylmuramyl-L-valyl-D-isoglutamine methyl ester (quinonyl-MDP-66) on various functions of macrophages was examined. Mouse peritoneal macrophages, when treated either in vitro or in vivo with quinonyl-MDP-66 suspended in phosphate-buffered saline, showed a capacity for cytolysis and cytostasis against tumor targets and released H2O2 in the presence of phorbol myristate acetate. The macrophages induced by quinonyl-MDP-66 also had both antibody-dependent cell-mediated cytotoxicity and phagocytic activity against erythroid targets. The fact that synthetic quinonyl-MDP-66 stimulates the macrophages to become more cytotoxic than do other MDP analogs suggests that the lipophilic residue (QS-10) in quinonyl-MDP-66 may be important for the development of this activity.
研究了6-O-QS-10-N-乙酰胞壁酰-L-缬氨酰-D-异谷氨酰胺甲酯(喹啉基-MDP-66)对巨噬细胞各种功能的影响。当用悬浮于磷酸盐缓冲盐水中的喹啉基-MDP-66在体外或体内处理小鼠腹腔巨噬细胞时,这些巨噬细胞显示出对肿瘤靶标的细胞溶解和细胞抑制能力,并在佛波酯肉豆蔻酸酯存在下释放过氧化氢。喹啉基-MDP-66诱导的巨噬细胞还具有抗体依赖性细胞介导的细胞毒性和对红细胞靶标的吞噬活性。合成的喹啉基-MDP-66比其他MDP类似物更能刺激巨噬细胞变得更具细胞毒性,这一事实表明喹啉基-MDP-66中的亲脂性残基(QS-10)可能对这种活性的发展很重要。