Reisser D, Jeannin J F, Lagadec P, Martin F
J Biol Response Mod. 1985 Oct;4(5):460-3.
Muramyl dipeptide (MDP) has been tested for its ability to induce rat peritoneal macrophage tumoricidal activity. Rat resident macrophages were activated in vivo and in vitro. Nevertheless, they were cytolytic when harvested 1 or 2 h after an intraperitoneal injection of MDP, but noncytolytic when harvested later. The activation obtained in vivo and in vitro with small amounts of MDP was not increased with larger doses. As, under the same conditions, mouse peritoneal macrophages were not activated, the sensitivity of the peritoneal macrophages to MDP depends on the species used.
已对胞壁酰二肽（MDP）诱导大鼠腹腔巨噬细胞杀肿瘤活性的能力进行了测试。大鼠常驻巨噬细胞在体内和体外均被激活。然而，在腹腔注射MDP后1或2小时收获时，它们具有细胞溶解作用，但在稍后收获时则无细胞溶解作用。用少量MDP在体内和体外获得的激活作用不会因较大剂量而增强。由于在相同条件下小鼠腹腔巨噬细胞未被激活，腹腔巨噬细胞对MDP的敏感性取决于所用的物种。
Zotero 插件