Serra H M, Galmarini M, Vottero-Cima E, Riera C M
Int J Immunopharmacol. 1983;5(1):67-70. doi: 10.1016/0192-0561(83)90073-5.
It was found that the organ specific hemagglutinating autoantibodies to rat male accessory glands can be suppressed by the injection of a single dose of cyclophosphamide applied 3 days after the first immunization. On the other hand, injection of the drug 3 days before immunization did not modify the response, that is, there were comparable incidence and titers in both treated and the control animals. Cyclophosphamide did not appear to act on the homocytotropic antibodies. These results indicate that cyclophosphamide acts only when it is administered after antigenic stimulation, to suppress hemagglutinating antibodies production.
研究发现，在首次免疫后3天注射单剂量环磷酰胺可抑制针对大鼠雄性附属性腺的器官特异性血凝自身抗体。另一方面，在免疫前3天注射该药物并未改变反应，也就是说，治疗组和对照组动物的发病率和滴度相当。环磷酰胺似乎对亲同种细胞抗体不起作用。这些结果表明，环磷酰胺仅在抗原刺激后给药时才起作用，以抑制血凝抗体的产生。
