Pistoresi-Palencia M C, Riera C M, Galmarini M, Vottero-Cima E, Serra H M
Immunology. 1984 Sep;53(1):141-5.
Passive transfer of antibody across the placenta or in milk has been thought to have a regulatory effect on the immune responsiveness of young animals. The effect of maternal antibody against rat male accessory glands (MRAG) on the systemic autoimmune responses of rat kits was studied. Serum obtained during the nursing period from female rats immunized with 5 mg/0.5 ml of MRAG or human serum albumin (HSA) emulsified in Freund's complete adjuvant before and during pregnancy contained anti-MRAG or anti-HSA, respectively. Kits born to MRAG-immunized dams were intradermally immunized with 5 mg/0.5 ml of MRAG-CFA at 21 and 51 days of age. Control kits from dams immunized with 5 mg/0.5 ml of human serum albumin emulsified in Freund's complete adjuvant (HSA-FCA) were similarly immunized with MRAG-FCA. Delayed-type hypersensitivity (DTH) studied 13 days after immunization with MRAG given at 21 days of age was significantly reduced only in the male kits born to MRAG-immunized dams compared with that of male kits from HSA-immunized dams (P less than 0.005). This hyporesponsiveness was not found in female kits from dams immunized with MRAG-FCA. The titre of circulating anti-MRAG studied at 65 days of age in kits born to MRAG-immunized dams approximated that in control kits. Antibodies against MRAG passively acquired from MRAG-immunized mothers did not alter the humoral autoimmune response of their kits.
抗体经胎盘或通过乳汁的被动转移被认为对幼龄动物的免疫反应性具有调节作用。研究了母体抗大鼠雄性附属性腺抗体（MRAG）对大鼠幼崽全身自身免疫反应的影响。在哺乳期从怀孕前及怀孕期间用5mg/0.5ml MRAG或人血清白蛋白（HSA）与弗氏完全佐剂乳化后免疫的雌性大鼠获得的血清，分别含有抗MRAG或抗HSA。MRAG免疫母鼠所生的幼崽在21日龄和51日龄时皮内注射5mg/0.5ml MRAG-弗氏完全佐剂（MRAG-CFA）。用弗氏完全佐剂乳化的5mg/0.5ml人血清白蛋白（HSA-FCA）免疫的母鼠所生的对照幼崽，同样用MRAG-FCA进行免疫。与HSA免疫母鼠所生的雄性幼崽相比，仅在MRAG免疫母鼠所生的雄性幼崽中，在21日龄注射MRAG后13天研究的迟发型超敏反应（DTH）显著降低（P小于0.005）。在用MRAG-FCA免疫的母鼠所生的雌性幼崽中未发现这种低反应性。在MRAG免疫母鼠所生的幼崽65日龄时研究的循环抗MRAG滴度与对照幼崽相近。从MRAG免疫的母亲被动获得的抗MRAG抗体并未改变其幼崽的体液自身免疫反应。
