Schwartz G E, Fair P L, Mandel M R, Salt P, Mieske M, Klerman G L
Psychosom Med. 1978 Jun;40(4):355-60. doi: 10.1097/00006842-197806000-00008.
Depressed patients who showed decreases in resting corrugator muscle tension levels, as measured electromyographically, also showed improvement in clinical symptoms, as assessed by the Hamilton Psychiatric Rating Scale over a 2-week period. Patients showing good clinical improvement after 2 weeks had resting pretreatment corrugator levels higher than those showing little clinical improvement, suggesting that corrugator activity might also serve as a forecaster of subsequent change. These findings support Darwin's 1872 hypothesis concerning the role of the "grief" muscle in depression. Furthermore, psychophysiological recording of patterns of facial muscle activity may have value in the clinical assessment of depression and treatment effects.
通过肌电图测量显示静息皱眉肌肌张力水平降低的抑郁症患者，在为期2周的时间里，经汉密尔顿精神病评定量表评估，其临床症状也有所改善。2周后临床改善良好的患者，其治疗前静息皱眉肌水平高于临床改善甚微的患者，这表明皱眉肌活动也可能是后续变化的一个预测指标。这些发现支持了达尔文在1872年提出的关于“悲伤”肌肉在抑郁症中作用的假说。此外，面部肌肉活动模式的心理生理学记录可能在抑郁症的临床评估和治疗效果评估中具有价值。
