Hawkins R A, Mazziotta J C, Phelps M E, Huang S C, Kuhl D E, Carson R E, Metter E J, Riege W H
J Cereb Blood Flow Metab. 1983 Jun;3(2):250-3. doi: 10.1038/jcbfm.1983.34.
Measurement of the local cerebral metabolic rate of glucose (LCMRGlc) with the fluorodeoxyglucose (FDG) method requires the utilization of appropriate values for the rate constants of the transport and phosphorylation processes. We measured these rate constants as a function of age to determine whether a decline in LCMRGlc as a function of age, in prior studies with the FDG method, actually represents changes in the rate constants. We found that measurements of LCMRGlc are not significantly affected by changes in rate constants as a function of aging, and that LCMRGlc did not change significantly with age.
采用氟代脱氧葡萄糖（FDG）法测量局部脑葡萄糖代谢率（LCMRGlc）需要运用合适的转运和磷酸化过程速率常数。我们测量了这些速率常数随年龄的变化情况，以确定在之前使用FDG法的研究中，LCMRGlc随年龄下降是否实际上代表了速率常数的变化。我们发现，LCMRGlc的测量值不会因速率常数随年龄变化而受到显著影响，并且LCMRGlc不会随年龄显著变化。
