Reivich M, Alavi A, Wolf A, Fowler J, Russell J, Arnett C, MacGregor R R, Shiue C Y, Atkins H, Anand A
J Cereb Blood Flow Metab. 1985 Jun;5(2):179-92. doi: 10.1038/jcbfm.1985.24.
The rate constants and lumped constants (LCs) for [18F]fluorodeoxyglucose ([18F]FDG) and [11C]deoxyglucose ([11C]DG) were determined in humans for the glucose metabolic rate kinetic model used to measure local cerebral glucose consumption. The mean values (+/- SE) of the LCs for [18F]FDG and [11C]DG are 0.52 +/- 0.028 (n = 9) and 0.56 +/- 0.043 (n = 6), respectively. The mean values (+/- SE) of the rate constants k1, k2, k3, and k4 for [18F]FDG for gray matter are 0.095 +/- 0.005, 0.125 +/- 0.002, 0.069 +/- 0.002, and 0.0055 +/- 0.0003, respectively. The corresponding values for white matter are 0.065 +/- 0.005, 0.126 +/- 0.003, 0.066 +/- 0.002, and 0.0054 +/- 0.0006, respectively. Using these values and previously published values for the rate constants for [11C]DG, the average whole-brain metabolic rates for glucose in normal subjects measured with [18F]FDG and [11C]DG are 5.66 +/- 0.37 (n = 6) and 4.99 +/- 0.23 (n = 6) mg/100 g/min, respectively. These values are not significantly different (t = 1.56, p greater than 0.10) and agree well with reported values in the literature determined by means of the Kety-Schmidt technique.
针对用于测量局部脑葡萄糖消耗的葡萄糖代谢率动力学模型，在人体中测定了[18F]氟脱氧葡萄糖（[18F]FDG）和[11C]脱氧葡萄糖（[11C]DG）的速率常数和集总常数（LCs）。[18F]FDG和[11C]DG的LCs平均值（±标准误）分别为0.52±0.028（n = 9）和0.56±0.043（n = 6）。[18F]FDG灰质的速率常数k1、k2、k3和k4的平均值（±标准误）分别为0.095±0.005、0.125±0.002、0.069±0.002和0.0055±0.0003。白质的相应值分别为0.065±0.005、0.126±0.003、0.066±0.002和0.0054±0.0006。使用这些值以及先前发表的[11C]DG速率常数的值，用[18F]FDG和[11C]DG测量的正常受试者全脑葡萄糖平均代谢率分别为5.66±0.37（n = 6）和4.99±0.23（n = 6）mg/100 g/min。这些值无显著差异（t = 1.56，p＞0.10），并且与通过Kety-Schmidt技术测定的文献报道值非常吻合。
