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Rapid determination of metoprolol and alpha-hydroxymetoprolol in human plasma and urine by high-performance liquid chromatography.

作者信息

Lennard M S, Silas J H

出版信息

J Chromatogr. 1983 Jan 14;272(1):205-9. doi: 10.1016/s0378-4347(00)86120-4.

DOI:10.1016/s0378-4347(00)86120-4
PMID:6841542
Abstract
摘要

相似文献

1
Rapid determination of metoprolol and alpha-hydroxymetoprolol in human plasma and urine by high-performance liquid chromatography.高效液相色谱法快速测定人血浆和尿液中的美托洛尔及α-羟基美托洛尔
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Simultaneous determination of metoprolol and alpha-hydroxymetoprolol in human plasma and urine by liquid chromatography with a preliminary observation on metoprolol oxidation in Japanese subjects.液相色谱法同时测定人血浆和尿液中的美托洛尔及α-羟基美托洛尔，并对日本受试者中美托洛尔的氧化进行初步观察。
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Determination of metoprolol and alpha-hydroxymetoprolol in plasma by high-performance liquid chromatography.
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High-performance liquid chromatographic determination of metoprolol and alpha-hydroxymetoprolol concentrations in human serum, urine, and cerebrospinal fluid.高效液相色谱法测定人血清、尿液和脑脊液中美托洛尔及α-羟基美托洛尔的浓度。
J Pharm Sci. 1984 Jul;73(7):961-3. doi: 10.1002/jps.2600730725.
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Determination of metoprolol and its two metabolites in human plasma and urine by high performance liquid chromatography with fluorescence detection and its application in pharmacokinetics.高效液相色谱荧光检测法测定人血浆和尿液中的美托洛尔及其两种代谢物及其在药代动力学中的应用。
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Determination of the new beta-blocker bisoprolol and of metoprolol, atenolol and propranolol in plasma and urine by high-performance liquid chromatography.用高效液相色谱法测定血浆和尿液中新型β受体阻滞剂比索洛尔以及美托洛尔、阿替洛尔和普萘洛尔的含量。
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Assay of metoprolol and alpha-hydroxymetoprolol in human urine by reversed-phase liquid chromatography with direct-injection.采用直接进样反相液相色谱法测定人尿中的美托洛尔和α-羟基美托洛尔。
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Determination of metoprolol and its alpha-hydroxylated metabolite in human plasma by high-performance liquid chromatography.
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Liquid chromatographic separation of the enantiomers of metoprolol and its alpha-hydroxy metabolite on Chiralcel OD for determination in plasma and urine.在Chiralcel OD上对美托洛尔对映体及其α-羟基代谢物进行液相色谱分离，用于血浆和尿液中的测定。
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Stereoselective metabolism of metoprolol: enantioselectivity of alpha-hydroxymetoprolol in plasma and urine.
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引用本文的文献

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Metabolic ratios of four probes of CYP2D6 in Turkish subjects: a cross-over study.土耳其受试者中CYP2D6四种探针的代谢比率：一项交叉研究。
Eur J Drug Metab Pharmacokinet. 1996 Oct-Dec;21(4):309-14. doi: 10.1007/BF03189732.
2
Metoprolol alpha-hydroxylation is a poor probe for debrizoquine oxidation (CYP2D6) polymorphism in Jordanians.在约旦人中，美托洛尔α-羟化作用对于地布喹氧化（CYP2D6）多态性而言并非良好的检测指标。
Eur J Clin Pharmacol. 1994;47(4):311-4. doi: 10.1007/BF00191160.
3
Comparison of two slow-release formulations of metoprolol with conventional metoprolol and atenolol in hypertensive patients.
美托洛尔两种缓释制剂与传统美托洛尔及阿替洛尔在高血压患者中的比较。
Br J Clin Pharmacol. 1985 Oct;20(4):387-91. doi: 10.1111/j.1365-2125.1985.tb05082.x.
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Polymorphic metabolism of metoprolol: clinical studies.美托洛尔的多态性代谢：临床研究
Eur J Clin Pharmacol. 1985;28 Suppl:85-8. doi: 10.1007/BF00543716.
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Influence of nitrendipine and verapamil on plasma levels, urinary excretion, and beta-blocking effect of metoprolol.尼群地平和维拉帕米对美托洛尔血浆浓度、尿排泄及β受体阻滞作用的影响。
Cardiovasc Drugs Ther. 1988 Jul;2(2):205-9. doi: 10.1007/BF00051235.
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Metoprolol metabolism and debrisoquine oxidation polymorphism--population and family studies.美托洛尔代谢与异喹胍氧化多态性——群体与家系研究
Br J Clin Pharmacol. 1985 Dec;20(6):555-66. doi: 10.1111/j.1365-2125.1985.tb05112.x.