大鼠下丘脑体外释放神经降压素。

Neurotensin release from rat hypothalamus in vitro.

作者信息

Shennan K I, Sheppard M C

出版信息

J Endocrinol. 1983 Apr;97(1):105-11. doi: 10.1677/joe.0.0970105.

DOI:10.1677/joe.0.0970105

Abstract

Neurotensin is a hypothalamic peptide which inhibits secretion of TSH in the rat in vivo. We have demonstrated a calcium-dependent release of neurotensin from incubated rat hypothalamus in response to depolarizing stimuli, as well as a dose-dependent stimulatory effect of tri-iodothyronine (T3) on neurotensin secretion. We suggest that part of the neuroendocrine control of TSH secretion involves the interaction of T3, neurotensin and TSH; the presence of neurotensin in extracts of anterior pituitary gland is further evidence for its hypophysiotrophic role.

摘要

神经降压素是一种下丘脑肽，它在体内可抑制大鼠促甲状腺激素（TSH）的分泌。我们已经证明，在体外培养的大鼠下丘脑中，去极化刺激可引起神经降压素的钙依赖性释放，同时三碘甲状腺原氨酸（T3）对神经降压素的分泌具有剂量依赖性刺激作用。我们认为，TSH分泌的部分神经内分泌控制涉及T3、神经降压素和TSH之间的相互作用；垂体前叶提取物中存在神经降压素，进一步证明了其对垂体的营养作用。