Berardelli A, Sabra A F, Hallett M
J Neurol Neurosurg Psychiatry. 1983 Jan;46(1):45-53. doi: 10.1136/jnnp.46.1.45.
Electromyographic responses of triceps surae and tibialis anterior produced by dorsiflexion stretch were studied in 17 patients with Parkinson's disease. Most patients showed increased muscular activity when attempting to relax. A few patients showed an increase of short-latency reflexes when relaxed and when exerting a voluntary plantarflexion prior to the stretch. Many patients showed long-latency reflexes when relaxed and all but one showed long-latency reflexes with voluntary contraction; and these reflexes were often larger in magnitude and longer in duration than those seen in normal subjects. Unlike the short-latency reflex, the long-latency reflex did not disappear with vibration applied to the Achilles tendon. The long-latency reflexes and continuous responses to slow ramp stretches were diminished at a latency similar to the beginning of long-latency reflexes when the stretching was quickly reversed. Dorsiflexion stretch also frequently produced a shortening reaction in tibialis anterior. Of all the abnormal behavior exhibited by the Parkinsonian patients only the long-latency reflex magnitude and duration correlated with the clinical impression of increased tone. The mechanism of the long-latency reflex to stretch which is responsible for rigidity is not certain, but the present results are consistent with a group II mediated tonic response.
对17例帕金森病患者进行了背屈拉伸诱发的腓肠肌三头肌和胫骨前肌肌电图反应的研究。大多数患者在试图放松时肌肉活动增加。少数患者在放松时以及在拉伸前进行自主跖屈时，短潜伏期反射增强。许多患者在放松时出现长潜伏期反射，除1例患者外，其余患者在自主收缩时均出现长潜伏期反射；并且这些反射在幅度上通常更大，持续时间更长，比正常受试者所见的反射更明显。与短潜伏期反射不同，对跟腱施加振动时，长潜伏期反射不会消失。当快速反转拉伸时，长潜伏期反射和对缓慢斜坡拉伸的持续反应在类似于长潜伏期反射开始的潜伏期时减弱。背屈拉伸还经常在胫骨前肌中产生缩短反应。在帕金森病患者表现出的所有异常行为中，只有长潜伏期反射的幅度和持续时间与肌张力增高的临床印象相关。导致僵硬的长潜伏期拉伸反射的机制尚不确定，但目前的结果与II类介导的强直反应一致。
