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进行性软脑膜纤维化:一例临床病理病例报告

Progressive leptomeningeal fibrosis: a clinico-pathological case report.

作者信息

Chalif D, Duchen L W, Marshall J, Hayward R

出版信息

J Neurol Neurosurg Psychiatry. 1983 Mar;46(3):261-5. doi: 10.1136/jnnp.46.3.261.

DOI:10.1136/jnnp.46.3.261
PMID:6842233
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1027334/
Abstract

A female patient developed persistent facial pain beginning at age 19 years. Intermittent motor and sensory disturbances referable to one hemisphere began nine years later and by the age of 41 she had developed signs of increased intracranial pressure. Exploratory craniotomy revealed replacement of the leptomeninges by thick, fibrous tissue. The histological appearance was that of a chronic, benign and minimally infiltrative process with a mild, non-specific inflammatory component, underlying cortical ischaemic changes, and white matter oedema. The lesion resembled nodular fasciitis, a soft tissue process. No cause of the reactive fibrosis of the meninges in this case is known.

摘要

一名女性患者19岁时开始出现持续性面部疼痛。9年后,一侧半球出现间歇性运动和感觉障碍,到41岁时,她出现了颅内压升高的迹象。 exploratory开颅手术显示软脑膜被增厚的纤维组织取代。组织学表现为慢性、良性且浸润轻微的过程,伴有轻度非特异性炎症成分、潜在的皮质缺血性改变和白质水肿。该病变类似于结节性筋膜炎,一种软组织病变。本病例中脑膜反应性纤维化的病因不明。 (注:原文中“Exploratory”翻译为“ exploratory”可能有误,推测可能是“Exploratory”,意为“探索性的”,这里暂且按推测翻译)

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4db5/1027334/877f65ab4b5f/jnnpsyc00131-0074-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4db5/1027334/04e0d756f4ab/jnnpsyc00131-0072-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4db5/1027334/44f48fa5d75c/jnnpsyc00131-0073-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4db5/1027334/be52873ad54a/jnnpsyc00131-0073-b.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4db5/1027334/877f65ab4b5f/jnnpsyc00131-0074-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4db5/1027334/04e0d756f4ab/jnnpsyc00131-0072-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4db5/1027334/44f48fa5d75c/jnnpsyc00131-0073-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4db5/1027334/be52873ad54a/jnnpsyc00131-0073-b.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4db5/1027334/877f65ab4b5f/jnnpsyc00131-0074-a.jpg

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本文引用的文献

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