Carelli V, Di Colo G
J Pharm Sci. 1983 Mar;72(3):316-7. doi: 10.1002/jps.2600720329.
The ability of ethylene glycol; glycerin; polyethylene glycols 200, 400, and 6000; polysorbate 80; and lactose dispersed in silicone rubber, to promote water sorption into the polymer was investigated in water and in isotonic (pH 7.4) phosphate buffer. Polyethylene glycols 200 and 400, lactose, and, especially, glycerin were effective water carriers. Marked differences in the kinetics of rubber swelling were observed, depending on the carrier. The swelling patterns relative to ethylene glycol, glycerin, and polyethylene glycol 200 showed a maximum due to significant leaching of these additives from the polymer. Steady swelling degrees were afforded by polyethylene glycols 400 and 6000 and by polysorbate 80. The interdependent processes of polymer imbibition and carrier release were speeded up without altering their kinetic patterns by increasing the initial surface-volume ratio of the devices. A proportionality resulted between maximal swelling and initial carrier concentration, although the swelling patterns were substantially unaffected by this variable.
研究了乙二醇、甘油、聚乙二醇200、400和6000、聚山梨酯80以及分散在硅橡胶中的乳糖促进水吸附到聚合物中的能力，实验环境为水和等渗（pH 7.4）磷酸盐缓冲液。聚乙二醇200和400、乳糖，尤其是甘油，是有效的水载体。观察到橡胶溶胀动力学存在显著差异，这取决于载体。相对于乙二醇、甘油和聚乙二醇200的溶胀模式出现最大值，这是由于这些添加剂从聚合物中大量浸出所致。聚乙二醇400和6000以及聚山梨酯80能产生稳定的溶胀度。通过增加装置的初始表面积与体积比，聚合物吸收和载体释放的相互依存过程加快，但不改变其动力学模式。尽管溶胀模式基本上不受该变量影响，但最大溶胀与初始载体浓度之间存在比例关系。
