McGinity J W, Hunke L A, Combs A B
J Pharm Sci. 1979 May;68(5):662-4. doi: 10.1002/jps.2600680544.
The influence of gelatin, sodium lauryl sulfate, lactose, and sodium alginate on morphine sulfate diffusion from cylindrical silicone polymer pellets was examined in isotonic pH 7.4 phosphate buffer. These water-soluble carriers caused the pellets to swell in aqueous media. Sodium alginate exerted the greatest influence on drug release. The morphine sulfate diffusion rate from the cylindrical pellets increased as the matrix alginate content increased up to 20%. Water-soluble carrier incorporation into silicone polymeric matrixes permits controlled release of water-soluble drugs that otherwise would be released extremely slowly from the polymer. Drug diffusion from the silicone matrix containing sodium alginate followed second-order kinetics. The release mechanism probably involves the creation of pores or pathways through the matrix secondary to the swelling.
在等渗pH 7.4磷酸盐缓冲液中，研究了明胶、十二烷基硫酸钠、乳糖和海藻酸钠对硫酸吗啡从圆柱形硅酮聚合物微丸中扩散的影响。这些水溶性载体使微丸在水性介质中膨胀。海藻酸钠对药物释放的影响最大。随着基质中海藻酸钠含量增加至20%，圆柱形微丸中硫酸吗啡的扩散速率增加。将水溶性载体掺入硅酮聚合物基质中可实现水溶性药物的控释，否则这些药物会从聚合物中极缓慢地释放。硫酸吗啡从含海藻酸钠的硅酮基质中的扩散遵循二级动力学。释放机制可能涉及由于溶胀而在基质中形成孔隙或通道。
