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核心技术专利：CN118964589B侵权必究

核心技术专利：CN118964589B侵权必究

Asatoor A M, Milne M D, Walshe J M

J R Coll Physicians Lond. 1983 Apr;17(2):122-5.

There is an excess urinary output of free amino acids and of urinary peptides in most cases of untreated Wilson's disease. Studies of 11 patients have shown that both these abnormalities are greatly improved by two years of standard chelation therapy. 2. The reduction in excretion of both free amino acids and peptides is purely quantitative, there being no significant change in the percentage composition of amino acids, either free or combined, in relation to their total urinary output. 3. Arguments are advanced that the peptiduria of the disease is usually due to a proximal renal tubular reabsorption defect, but in rare cases it may be due to excess bone breakdown or even to a combination of bone and renal tubular disease in the same patient.

在大多数未经治疗的威尔逊氏病病例中，游离氨基酸和尿肽的尿量排出过多。对11名患者的研究表明，经过两年的标准螯合疗法，这两种异常情况都有了很大改善。2. 游离氨基酸和肽类排泄量的减少纯粹是数量上的，游离或结合形式的氨基酸相对于其总尿量的百分比组成没有显著变化。3. 有人提出，该病的肽尿通常是由于近端肾小管重吸收缺陷，但在罕见情况下，可能是由于骨分解过多，甚至是同一患者的骨病和肾小管疾病共同作用所致。

Asatoor A M, Milne M D, Walshe J M

J R Coll Physicians Lond. 1983 Apr;17(2):122-5.

There is an excess urinary output of free amino acids and of urinary peptides in most cases of untreated Wilson's disease. Studies of 11 patients have shown that both these abnormalities are greatly improved by two years of standard chelation therapy. 2. The reduction in excretion of both free amino acids and peptides is purely quantitative, there being no significant change in the percentage composition of amino acids, either free or combined, in relation to their total urinary output. 3. Arguments are advanced that the peptiduria of the disease is usually due to a proximal renal tubular reabsorption defect, but in rare cases it may be due to excess bone breakdown or even to a combination of bone and renal tubular disease in the same patient.

在大多数未经治疗的威尔逊氏病病例中，游离氨基酸和尿肽的尿量排出过多。对11名患者的研究表明，经过两年的标准螯合疗法，这两种异常情况都有了很大改善。2. 游离氨基酸和肽类排泄量的减少纯粹是数量上的，游离或结合形式的氨基酸相对于其总尿量的百分比组成没有显著变化。3. 有人提出，该病的肽尿通常是由于近端肾小管重吸收缺陷，但在罕见情况下，可能是由于骨分解过多，甚至是同一患者的骨病和肾小管疾病共同作用所致。