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核心技术专利：CN118964589B侵权必究

核心技术专利：CN118964589B侵权必究

Asatoor A M, Miline M D, Walshe J M

Clin Sci Mol Med. 1976 Oct;51(4):369-78. doi: 10.1042/cs0510369.

A study has been made of peptide excretion in twenty cases of Wilson's disease, ligand-exchange column chromatography being used to separate peptides from free amino acids. Previous reports of excess of peptide output in the disease were confirmed and the excess was shown to be highly significant statistically. 2. A considerable fraction of the excess of peptide output was shown to consist of hydroxyproline-containing peptides derived from collagen degradation. 3. The method of rank correlation showed that the difference both in free amino acid and peptide-bound amino acid output in cases of Wilson's disease and in control subjects was mainly quantitative; the pattern of amino acid excretion was qualitatively similar in both groups. 4. Evidence is presented that the increase copper output in the urine in the disease is not secondary to peptiduria.

对20例威尔逊氏病患者的肽排泄情况进行了研究，采用配体交换柱色谱法从游离氨基酸中分离肽。该疾病中肽输出过量的先前报道得到了证实，且过量在统计学上具有高度显著性。2. 结果表明，过量肽输出的相当一部分是由胶原蛋白降解产生的含羟脯氨酸肽组成。3. 秩相关方法表明，威尔逊氏病患者与对照组在游离氨基酸和肽结合氨基酸输出方面的差异主要是数量上的；两组氨基酸排泄模式在质量上相似。4. 有证据表明，该疾病中尿铜输出增加并非肽尿的继发结果。

Asatoor A M, Miline M D, Walshe J M

Clin Sci Mol Med. 1976 Oct;51(4):369-78. doi: 10.1042/cs0510369.

A study has been made of peptide excretion in twenty cases of Wilson's disease, ligand-exchange column chromatography being used to separate peptides from free amino acids. Previous reports of excess of peptide output in the disease were confirmed and the excess was shown to be highly significant statistically. 2. A considerable fraction of the excess of peptide output was shown to consist of hydroxyproline-containing peptides derived from collagen degradation. 3. The method of rank correlation showed that the difference both in free amino acid and peptide-bound amino acid output in cases of Wilson's disease and in control subjects was mainly quantitative; the pattern of amino acid excretion was qualitatively similar in both groups. 4. Evidence is presented that the increase copper output in the urine in the disease is not secondary to peptiduria.

对20例威尔逊氏病患者的肽排泄情况进行了研究，采用配体交换柱色谱法从游离氨基酸中分离肽。该疾病中肽输出过量的先前报道得到了证实，且过量在统计学上具有高度显著性。2. 结果表明，过量肽输出的相当一部分是由胶原蛋白降解产生的含羟脯氨酸肽组成。3. 秩相关方法表明，威尔逊氏病患者与对照组在游离氨基酸和肽结合氨基酸输出方面的差异主要是数量上的；两组氨基酸排泄模式在质量上相似。4. 有证据表明，该疾病中尿铜输出增加并非肽尿的继发结果。