Vreeburg J T, Groeneveld J O, Post P E, Ooms M P
J Reprod Fertil. 1983 May;68(1):171-5. doi: 10.1530/jrf.0.0680171.
Mean +/- s.d. testosterone concentrations in the peripheral plasma of 21- and 22-day-old male fetuses (1.32 +/- 0.43 ng/ml) were significantly (P less than 0.05) higher than those in the umbilical venous plasma (0.37 +/- 0.08 ng/ml). Testosterone concentrations in umbilical venous plasma of male and female (0.29 +/- 0.06 ng/ml) fetuses and in peripheral plasma of female fetuses (0.36 +/- 0.10 ng/ml) were not significantly different. Androsterone levels measured in umbilical venous plasma of male (11.5 +/- 2.5 ng/ml) and female (12.3 +/- 2.1 ng/ml) fetuses were nearly as high as those in peripheral plasma (males, 12.9 +/- 3.1; females, 13.3 +/- 3.5 ng/ml). There were high concentrations of androsterone in the placentas of male (33 +/- 4 ng/g) and female (33 +/- 5 ng/ml) fetuses, suggesting that this organ is the major source of fetal androsterone. We also conclude that a major part of the testosterone present in female fetuses is secreted by the placentas.
21日龄和22日龄雄性胎儿外周血浆中睾酮浓度的平均值±标准差为（1.32±0.43纳克/毫升），显著高于脐静脉血浆中的浓度（0.37±0.08纳克/毫升）（P<0.05）。雄性和雌性胎儿脐静脉血浆中的睾酮浓度（0.29±0.06纳克/毫升）以及雌性胎儿外周血浆中的睾酮浓度（0.36±0.10纳克/毫升）无显著差异。雄性胎儿（11.5±2.5纳克/毫升）和雌性胎儿（12.3±2.1纳克/毫升）脐静脉血浆中测得的雄酮水平与外周血浆中的水平相近（雄性，12.9±3.1；雌性，13.3±3.5纳克/毫升）。雄性胎儿（33±4纳克/克）和雌性胎儿（33±5纳克/毫升）胎盘内雄酮浓度较高，表明该器官是胎儿雄酮的主要来源。我们还得出结论，雌性胎儿体内存在的睾酮主要由胎盘分泌。
