采用放疗前化疗治疗晚期精原细胞瘤。

Treatment of advanced seminoma with pre-radiation chemotherapy.

作者信息

Crawford E D, Smith R B, deKernion J B

出版信息

J Urol. 1983 Apr;129(4):752-6. doi: 10.1016/s0022-5347(17)52341-1.

Abstract

Seminoma is one of the most radiosensitive of solid tumors. However, the survival rate of patients with clinically advanced stages B3 and C disease is poor. Because of this dismal prognosis we instituted a protocol of pre-radiation chemotherapy in an attempt to improve the survival rates. A chemotherapeutic regimen, consisting of 2 to 3 courses of vincristine, actinomycin D and cyclophosphamide, was administered before radiotherapy. Of 16 patients studied 15 (93.7 per cent) had a complete response to the combined treatment regimen. We believe that pre-radiation chemotherapy is indicated in all patients with advanced seminoma.

摘要

精原细胞瘤是实体瘤中对放疗最敏感的肿瘤之一。然而，临床晚期B3和C期疾病患者的生存率较低。鉴于这种预后不佳的情况，我们制定了一项放疗前化疗方案，试图提高生存率。在放疗前给予一个由2至3个疗程的长春新碱、放线菌素D和环磷酰胺组成的化疗方案。在研究的16例患者中，15例（93.7%）对联合治疗方案有完全反应。我们认为，所有晚期精原细胞瘤患者均应进行放疗前化疗。