高剂量环磷酰胺作为晚期精原细胞瘤放疗的辅助治疗手段。

High dose cyclophosphamide as an adjunct to radiotherapy for advanced seminoma.

作者信息

Weitzman S A, Carey R W

出版信息

J Urol. 1977 May;117(5):613-4. doi: 10.1016/s0022-5347(17)58554-7.

Abstract

Two patients with far-advanced seminoma of the testis were given single intravenous injections of high dose (1.5 and 2.0 gm. per m.) cyclophosphamide. Both patients experienced prompt, dramatic objective regressions without severe toxicity. Definitive radiotherapy, deemed technically unfeasible before cyclophosphamide administration, was administered subsequently. Long-term complete remissions (more than 16 and 28 months) have been attained in both patients. High dose cyclophosphamide may prove useful in selected patients with disseminated seminoma.

摘要

两名患有晚期睾丸精原细胞瘤的患者接受了大剂量（每平方米1.5克和2.0克）环磷酰胺的单次静脉注射。两名患者均迅速出现显著的客观缓解，且无严重毒性。在使用环磷酰胺之前被认为技术上不可行的根治性放疗随后进行。两名患者均已获得长期完全缓解（超过16个月和28个月）。大剂量环磷酰胺可能对某些播散性精原细胞瘤患者有用。