Ito A, Shindo K, Sakamoto H, Sano F, Ishigatsubo Y, Matsumura M, Tani K, Maruta I, Kodama F, Fukushima K
Jpn J Antibiot. 1983 Jan;36(1):84-92.
Ten patients with sepsis and pneumonia complicated by leukemia or lung cancer were treated with cefoxitin (CFX) at daily dose of 6 g. The following results were obtained. 1. Clinical effects of CFX were good in 5 patients, fair in 2 and poor in 3 with effective rate of 50%. 2. Out of 8 patients with sepsis, 5 showed good response to CFX and effective rate was 62.5%. 3. Bacteriological outcomes were eradicated in 1, unchanged in 1, replaced in 2 and unknown in 6 cases. 4. Diarrhea was observed in 1 patient but this was not considered related to CFX therapy. 5. No abnormal laboratory finding due to CFX was observed. 6. It should be considered that 6 g or more of CFX is given in case of severe infections, such as sepsis or pneumonia complicated by serious underlying diseases.
10例合并白血病或肺癌的脓毒症和肺炎患者接受了头孢西丁（CFX）治疗，日剂量为6克。获得了以下结果。1. CFX的临床效果：5例良好，2例一般，3例较差，有效率为50%。2. 在8例脓毒症患者中，5例对CFX反应良好，有效率为62.5%。3. 细菌学结果：1例根除，1例无变化，2例替换，6例情况不明。4. 1例患者出现腹泻，但认为这与CFX治疗无关。5. 未观察到因CFX导致的实验室检查异常。6. 对于严重感染，如合并严重基础疾病的脓毒症或肺炎，应考虑给予6克或更多的CFX。
