Panagopoulos E, Murray D
J Surg Oncol. 1983 May;23(1):8-10. doi: 10.1002/jso.2930230104.
Thirty patients with metastatic malignant melanoma of unknown primary origin treated at Emory University Clinic between 1940 and 1975 are presented. This group represents the 4.4% of all melanomas treated during the same period of time at Emory. Nineteen (63.3%) patients had nodal metastases only, and they were handled by radical lymphadenectomy of the involved area. The remaining 11 patients presented with lung or widespread subcutaneous metastatic disease and treated with biopsy and radiotherapy or chemotherapy. The former group experienced 28.6% five- and ten-year actuarial survival while patients with lung metastases succumbed within four months after diagnosis. Spontaneous regression of a typical melanoma skin lesion has been reported in three patients prior to development of metastatic disease.
本文介绍了1940年至1975年间在埃默里大学诊所接受治疗的30例原发灶不明的转移性恶性黑色素瘤患者。该组患者占同期在埃默里接受治疗的所有黑色素瘤患者的4.4%。19例（63.3%）患者仅有淋巴结转移，对其进行了受累区域的根治性淋巴结清扫术。其余11例患者出现肺部或广泛的皮下转移疾病，接受了活检及放疗或化疗。前一组患者的5年和10年精算生存率为28.6%，而有肺转移的患者在诊断后4个月内死亡。3例患者在发生转移疾病之前，典型的黑色素瘤皮肤病变出现了自发消退。
