Wang T S, Lowe L, Smith J W, Francis I R, Sondak V K, Dworzanian L, Finkelstein S, Slingluff C L, Johnson T M
Department of Dermatology, University of Michigan Medical Center, Ann Arbor 48109-0314, USA.
Dermatol Surg. 1998 Aug;24(8):915-9. doi: 10.1111/j.1524-4725.1998.tb04275.x.
Complete spontaneous regression of melanoma metastatic to the lungs is a rare event.
To report a case of biopsy-proven melanoma metastatic to the lung with complete spontaneous regression.
Multidisciplinary case report.
A 35-year-old white female was diagnosed with metastatic melanoma to the lung. A pleural biopsy confirmed the diagnosis. Partial spontaneous regression was noted by a staging computed tomography scan prior to enrollment in an investigational protocol. Complete spontaneous regression occurred over 5 months without any form of conventional or alternative therapy, and the patient remains disease-free 3 years after diagnosis.
Our case represents the seventh case of complete spontaneous regression of melanoma metastatic to the lung, and the only case with histologic confirmation of both the primary and pulmonary metastatic lesions. The patient was pregnant twice between the time of her initial diagnosis of primary melanoma and pulmonary metastatic disease.
黑色素瘤转移至肺部后完全自发消退是一种罕见事件。
报告一例经活检证实为黑色素瘤肺转移且完全自发消退的病例。
多学科病例报告。
一名35岁白人女性被诊断为黑色素瘤肺转移。胸膜活检确诊。在纳入一项研究方案之前，分期计算机断层扫描显示部分自发消退。在未接受任何形式的传统或替代治疗的情况下，5个月内完全自发消退，且患者在诊断后3年仍无疾病。
我们的病例是黑色素瘤肺转移完全自发消退的第七例，也是唯一一例原发灶和肺转移灶均有组织学证实的病例。该患者在最初诊断原发性黑色素瘤至发生肺转移疾病期间怀孕两次。
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