Lopaschuk G D, Tahiliani A G, McNeill J H
J Pharmacol Methods. 1983 Feb;9(1):71-5. doi: 10.1016/0160-5402(83)90052-9.
Surgically implanted osmotic minipumps were used to continuously deliver insulin to chemically-induced diabetic rats. Serum glucose levels were maintained within normal limits for 7 days in all diabetic rats implanted with the minipumps. Beyond this time period, serum glucose levels could not be adequately controlled in greater than 50% of the diabetic rats. Seven of 20 diabetic rats originally implanted with osmotic minipumps were well controlled throughout the 31-day study period. This study demonstrates that insulin-filled osmotic minipumps provide no advantage over daily insulin injection in the long term control of diabetes.
通过外科手术植入的渗透式微型泵被用于持续向化学诱导的糖尿病大鼠输送胰岛素。在所有植入微型泵的糖尿病大鼠中，血清葡萄糖水平在7天内维持在正常范围内。超过这个时间段，超过50%的糖尿病大鼠的血清葡萄糖水平无法得到充分控制。在最初植入渗透式微型泵的20只糖尿病大鼠中，有7只在整个31天的研究期间血糖得到了良好控制。这项研究表明，在糖尿病的长期控制中，填充胰岛素的渗透式微型泵相比每日注射胰岛素并无优势。
