Moore K L, Bendick P J, Broadie T A, Bang N U, Glover J L
Med Instrum. 1983 Jan-Feb;17(1):85-7.
The hematological effects of autotransfusion have not been well characterized. A canine model was used in which a controlled 2000-ml blood loss was effected into the open peritoneum and replaced either by autotransfusion, using one of two devices, or by homologous transfusion. In each group hematological data were collected before, during, and after the operation. None of the parameters measured showed significant differences between the two autotransfused groups. However, intraoperative values for prothrombin time and activated partial thromboplastin time were significantly prolonged in the autotransfused groups compared with the homologous transfusion group. Fibrinogen levels and platelet counts fell significantly from baseline levels in the intraoperative period, but rose above even baseline levels postoperatively. White blood cell counts remained unchanged intraoperatively, but rose significantly and remained elevated at 24 hours and 1 week. No significant differences exist between the effects produced by the two autotransfusion systems. It is clear that prothrombin time and activated partial thromboplastin time are prolonged intraoperatively in the autotransfusion groups, whereas these parameters are unaffected by homologous transfusion.
自体输血的血液学效应尚未得到充分描述。使用了一种犬类模型，在该模型中，将2000毫升血液控制性失血至开放的腹腔内，然后使用两种设备之一进行自体输血或异体输血来补充失血。在每组中，在手术前、手术期间和手术后收集血液学数据。两个自体输血组之间测量的参数均未显示出显著差异。然而，与异体输血组相比，自体输血组的术中凝血酶原时间和活化部分凝血活酶时间显著延长。纤维蛋白原水平和血小板计数在术中较基线水平显著下降，但术后甚至升至基线水平以上。白细胞计数在术中保持不变，但在术后24小时和1周时显著升高并维持在较高水平。两种自体输血系统产生的效果之间没有显著差异。显然，自体输血组术中凝血酶原时间和活化部分凝血活酶时间延长，而异体输血对这些参数没有影响。
