[Developing a dose-administration schedule for drug therapy in childhood].

For the application of a target concentration strategy for the assessment of dosage regimens pharmacokinetic parameters and their variances must be known. Since pharmacokinetic parameters like the elimination constant or the volume of distribution undergo considerable changes during the perinatal period until early childhood, the application of standard dosage regimens may lead to serious under- or overtreatment. Based on kinetic data of children from the literature and own studies, it is demonstrated, how changes of the volume of distribution and of the elimination constant influence the optimal dosage regimen. The optimal dosage regimen is evaluated using a special criterion of optimality.