Hart J W, Hartley-Asp B
Mutat Res. 1983 May;120(2-3):127-32. doi: 10.1016/0165-7992(83)90153-7.
The early effects of X-rays, vincristine, cyclophosphamide, quinacrine dihydrochloride, cycloheximide, actinomycin D and hydroxyurea on the induction of micronuclei in mouse bone-marrow erythrocytes were studied. A significant increase in the incidence of micronuclei in polychromatic erythrocytes was seen as early as 5 h after a single treatment with vincristine, 6 h after treatment with X-rays and 10 h after treatment with cyclophosphamide. The cell kinetics of the mouse erythropoietic system described by Cole et al. (1981) can be modified to fit these results. According to this revised model, the final mitosis takes place only 5 h before the expulsion of the nucleus.
研究了X射线、长春新碱、环磷酰胺、二盐酸喹吖因、放线菌酮、放线菌素D和羟基脲对小鼠骨髓红细胞微核诱导的早期影响。在用长春新碱单次处理后5小时、用X射线处理后6小时以及用环磷酰胺处理后10小时，即可观察到多色红细胞中微核发生率显著增加。Cole等人（1981年）描述的小鼠红细胞生成系统的细胞动力学可进行修正以符合这些结果。根据这个修正后的模型，最终有丝分裂仅在细胞核排出前5小时发生。
