van Buul P P, van Buul-Offers S C
Department of Radiation Genetics and Chemical Mutagenesis, J.A. Cohen Institute, Sylvius Laboratories, Leiden, The Netherlands.
Mutat Res. 1988 Apr;198(2):263-8. doi: 10.1016/0027-5107(88)90002-4.
The X-ray induction of micronuclei and structural chromosomal aberrations was studied in bone-marrow cells of normal and dwarf (dw) mice in combination with thyroxine and/or prolactin treatment or otherwise. Hormone treatment clearly increased micronuclei induction but not chromosome breakage, suggesting that indirect effects were involved. Since no clear differences in the timing of the final stage of erythropoiesis could be found, it is likely that the indirect effects are mediated via the formation-differentiation kinetics of erythroblasts. The induction of reciprocal translocations by X-rays in stem cell spermatogonia of dwarf mice was lower than in normals and treatment with prolactin, growth hormone and/or thyroxin, did not influence the chromosomal radiosensitivity of spermatogonial stem cells.
