Martelli A, Cavanna M, Gambino V, Robbiano L, Brambilla G
Mutat Res. 1983 May;120(2-3):133-7. doi: 10.1016/0165-7992(83)90154-9.
The genotoxicity of cimetidine was examined in the hepatocyte primary culture/DNA-repair test and by the DNA-damage/alkaline-elution assay. A dose-dependent amount of unscheduled DNA synthesis was elicited by cimetidine, whereas DNA fragmentation occurred only in hepatocytes exposed to the highest (3 mM) concentration of the drug. These findings are in contrast with the negative results previously obtained in long-term and short-term carcinogenesis assays.
在肝细胞原代培养/DNA修复试验以及DNA损伤/碱性洗脱试验中检测了西咪替丁的遗传毒性。西咪替丁引发了剂量依赖性的非程序性DNA合成，而DNA片段化仅发生在暴露于最高浓度（3 mM）该药物的肝细胞中。这些发现与先前在长期和短期致癌试验中获得的阴性结果形成对比。
