• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

A comparative study of the properties of the catechol-O-methyltransferase inhibitors, U-0521 and tropolone acetamide, in rat perfused heart.

作者信息

Bryan L J, Fleig H, Trendelenburg U

出版信息

Naunyn Schmiedebergs Arch Pharmacol. 1983 Feb;322(1):6-19. doi: 10.1007/BF00649346.

DOI:10.1007/BF00649346
PMID:6843690
Abstract
摘要

相似文献

1
A comparative study of the properties of the catechol-O-methyltransferase inhibitors, U-0521 and tropolone acetamide, in rat perfused heart.大鼠离体灌流心脏中儿茶酚-O-甲基转移酶抑制剂U-0521与托酚酮乙酰胺性质的比较研究
Naunyn Schmiedebergs Arch Pharmacol. 1983 Feb;322(1):6-19. doi: 10.1007/BF00649346.
2
Comparison of the effects of tropolone, beta-thujaplicin and U-0521 on the extraneuronal accumulation of isoprenaline in guinea-pig trachealis smooth muscle cells. A quantitative fluorescence histochemical study.托酚酮、β-崖柏素和U-0521对豚鼠气管平滑肌细胞中异丙肾上腺素细胞外蓄积作用的比较。一项定量荧光组织化学研究。
Naunyn Schmiedebergs Arch Pharmacol. 1979 Jul;307(3):235-41. doi: 10.1007/BF00505939.
3
Effects of extraneuronal uptake inhibitors on the positive chronotropic response to isoprenaline and on the accumulation of isoprenaline in perfused rat heart after inhibition of catechol-O-methyl transferase.
Naunyn Schmiedebergs Arch Pharmacol. 1987 Feb;335(2):123-8. doi: 10.1007/BF00177712.
4
Changes in the incidence and duration of ventricular fibrillation in dependence on the extraneuronal accumulation of isoprenaline in the perfused rat heart.在灌注大鼠心脏中，室颤发生率和持续时间的变化取决于异丙肾上腺素在神经外的蓄积情况。
Naunyn Schmiedebergs Arch Pharmacol. 1985 Oct;331(1):76-81. doi: 10.1007/BF00498854.
5
Effects of extraneuronal accumulation of isoprenaline on cAMP production in perfused rat heart.异丙肾上腺素的神经元外积聚对灌注大鼠心脏中cAMP产生的影响。
Jpn J Pharmacol. 1990 Jul;53(3):375-80. doi: 10.1254/jjp.53.375.
6
Extraneuronal accumulation of isoproterenol in atria and ventricle of perfused rat heart.异丙肾上腺素在灌注大鼠心脏心房和心室中的神经元外蓄积。
Life Sci. 1988;42(7):753-7. doi: 10.1016/0024-3205(88)90647-9.
7
Extraneuronal removal, accumulation and O-methylation of isoprenaline in the perfused heart.灌注心脏中异丙肾上腺素的非神经元性清除、蓄积及O-甲基化作用
Naunyn Schmiedebergs Arch Pharmacol. 1974;283(2):191-218. doi: 10.1007/BF00501145.
8
Comparative effect of tropolone and diosmin on venous COMT and sympathetic activity in rat.托酚酮和地奥司明对大鼠静脉儿茶酚-O-甲基转移酶和交感神经活性的比较作用。
Arch Int Pharmacodyn Ther. 1986 Oct;283(2):312-20.
9
The determination of the rate constant for the efflux of an amine from efflux curves for amine and metabolite.根据胺及其代谢物的流出曲线确定胺流出的速率常数。
Naunyn Schmiedebergs Arch Pharmacol. 1978 Sep;304(2):147-55. doi: 10.1007/BF00495551.
10
Possible activation of intracellular beta-adrenoceptors by extraneuronally accumulated isoprenaline in perfused rat heart.灌注大鼠心脏中细胞外积聚的异丙肾上腺素可能激活细胞内β-肾上腺素能受体。
Naunyn Schmiedebergs Arch Pharmacol. 1988 May;337(5):531-8. doi: 10.1007/BF00182727.

引用本文的文献

1
Amezinium and debrisoquine are substrates of uptake1 and potent inhibitors of monoamine oxidase in perfused lungs of rats.阿米洛利和异喹胍是摄取1的底物，也是大鼠灌注肺中强效单胺氧化酶抑制剂。
Naunyn Schmiedebergs Arch Pharmacol. 1996 Apr;353(5):536-44. doi: 10.1007/BF00169173.
2
Evidence for saturation of catechol-O-methyltransferase by low concentrations of noradrenaline in perfused lungs of rats.低浓度去甲肾上腺素使大鼠灌注肺中儿茶酚-O-甲基转移酶饱和的证据。
Naunyn Schmiedebergs Arch Pharmacol. 1995 Apr;351(4):408-16. doi: 10.1007/BF00169082.
3
The isotope effect of tritium in 3H-noradrenaline.

本文引用的文献

1
The uptake of catechol amines at high perfusion concentrations in the rat isolated heart: A novel catechol amine uptake process.大鼠离体心脏在高灌注浓度下对儿茶酚胺的摄取：一种新的儿茶酚胺摄取过程。
Br J Pharmacol Chemother. 1965 Aug;25(1):18-33. doi: 10.1111/j.1476-5381.1965.tb01753.x.
2
CATECHOL-OMETHYL TRANSFERASE INHIBITORS. IN VITRO INHIBITION OF THE ENZYME IN MOUSE-BRAIN EXTRACT.儿茶酚 - O - 甲基转移酶抑制剂。对小鼠脑提取物中该酶的体外抑制作用。
Acta Pharmacol Toxicol (Copenh). 1964;21:205-14. doi: 10.1111/j.1600-0773.1964.tb01785.x.
3
OCCUPANCY OF ADRENERGIC RECEPTORS AND INHIBITION OF CATECHOL O-METHYL TRANSFERASE BY TROPOLONES.
3H-去甲肾上腺素中氚的同位素效应。
Naunyn Schmiedebergs Arch Pharmacol. 1983 Jun;323(2):128-40. doi: 10.1007/BF00634260.
4
The extraneuronal compartments for the distribution of isoprenaline in the rat heart.大鼠心脏中异丙肾上腺素分布的神经外间隙。
Naunyn Schmiedebergs Arch Pharmacol. 1983 Nov;324(3):169-79. doi: 10.1007/BF00503890.
5
Kinetics of the O-methylating system for isoprenaline in the trachea and aorta of rabbit.兔气管和主动脉中异丙肾上腺素O-甲基化系统的动力学
Naunyn Schmiedebergs Arch Pharmacol. 1984 Nov;328(1):56-61. doi: 10.1007/BF00496107.
6
The influence of inhibition of catechol-O-methyl transferase or of monoamine oxidase on the extraneuronal metabolism of 3H-(-)-noradrenaline in the rat heart.儿茶酚-O-甲基转移酶抑制或单胺氧化酶抑制对大鼠心脏中3H-(-)-去甲肾上腺素细胞外代谢的影响。
Naunyn Schmiedebergs Arch Pharmacol. 1984 Oct;327(4):285-92. doi: 10.1007/BF00506238.
7
The kinetic characteristics of the extraneuronal Q-methylating system of the dog saphenous vein and the supersensitivity to catecholamines caused by its inhibition.犬隐静脉神经外Q-甲基化系统的动力学特性及其抑制所引起的对儿茶酚胺的超敏反应。
Naunyn Schmiedebergs Arch Pharmacol. 1984 Aug;327(1):48-55. doi: 10.1007/BF00504991.
8
Kinetic constants of isoprenaline and corticosterone for extraneuronal uptake in different cell types from various tissues.不同组织中不同细胞类型对异丙肾上腺素和皮质酮的非神经元摄取动力学常数。
Naunyn Schmiedebergs Arch Pharmacol. 1984 Jan;325(1):54-61. doi: 10.1007/BF00507054.
9
Saturation of monoamine oxidase by intraneuronal noradrenaline accumulation.神经元内去甲肾上腺素积累导致单胺氧化酶饱和。
Naunyn Schmiedebergs Arch Pharmacol. 1984 Dec;328(2):135-41. doi: 10.1007/BF00512062.
10
The outward transport of catecholamines mediated by uptake2 of the rat heart.大鼠心脏摄取2介导的儿茶酚胺外向转运。
Naunyn Schmiedebergs Arch Pharmacol. 1985 Sep;330(3):203-11. doi: 10.1007/BF00572435.
托酚酮对肾上腺素能受体的占据及儿茶酚-O-甲基转移酶的抑制作用
J Med Chem. 1963 Nov;6:755-9. doi: 10.1021/jm00342a028.
4
The effect of 4-methyltropolone on the metabolism of adrenaline.4-甲基托酚酮对肾上腺素代谢的影响。
Can J Biochem Physiol. 1963 Jul;41:1581-7.
5
Statistical estimations in enzyme kinetics.酶动力学中的统计估计
Biochem J. 1961 Aug;80(2):324-32. doi: 10.1042/bj0800324.
6
The determination of enzyme inhibitor constants.酶抑制剂常数的测定
Biochem J. 1953 Aug;55(1):170-1. doi: 10.1042/bj0550170.
7
Affinities of catecholamines for extraneuronal uptake in smooth muscle cells in trachealis muscle of guinea-pig.儿茶酚胺对豚鼠气管平滑肌细胞非神经元摄取的亲和力。
Naunyn Schmiedebergs Arch Pharmacol. 1980 Mar;311(2):139-46. doi: 10.1007/BF00510252.
8
A mathematical model representing the extraneuronal O-methylating system of the perfused rat heart.一种代表灌注大鼠心脏细胞外O-甲基化系统的数学模型。
Naunyn Schmiedebergs Arch Pharmacol. 1980 Feb;311(1):17-32. doi: 10.1007/BF00500298.
9
Kinetic analyses of the mechanisms of action of inhibitors of the extraneuronal uptake of adrenaline in smooth muscle cells of guinea-pig trachea.
Naunyn Schmiedebergs Arch Pharmacol. 1981 Jan;315(3):249-54. doi: 10.1007/BF00499842.
10
A kinetic analysis of the extraneuronal uptake and metabolism of catecholamines.儿茶酚胺的神经外摄取与代谢的动力学分析。
Rev Physiol Biochem Pharmacol. 1980;87:33-115. doi: 10.1007/BFb0030896.