Aroyewun O O, Barr G A
Neuropharmacology. 1983 Mar;22(3):329-36. doi: 10.1016/0028-3908(83)90248-4.
Previous studies have reported age-related changes in opiate receptors and in their response to narcotics during the process of normal growth of the brain. By inducing alterations in this developmental sequence, the present study attempted to provide correlates of the opiate receptor system with naloxone-induced anorexia. Offspring of mothers treated with morphine (7.5 mg/kg twice daily, s.c.) or saline during pregnancy, and infants from untreated mothers given morphine (5 mg/kg), naltrexone (10 mg/kg) or saline subcutaneously on postnatal days 1-5, were tested at days 10, 12 and 14 for deprivation-induced milk consumption following an acute dose of naloxone (1 or 5 mg/kg, i.p.). Naloxone reduced the food intake of 10- and 12-day old infants chronically treated with morphine postnatally. At age 14, naloxone reduced the food consumed by all the pretreatment groups, and pretreatment with morphine altered the dose-response curves for feeding modulation induced by naloxone. Naloxone had no effect on the food consumed by 10- or 12-day old offspring of mothers treated with morphine or saline, or on those age-groups that received naltrexone chronically or saline pretreatments postnatally. The observed changes occurred in the absence of gross malformations, drug-withdrawal symptoms and differences in activity. These results demonstrate that opiate receptors may participate in feeding.
以往的研究报告了在大脑正常生长过程中阿片受体及其对麻醉品反应的年龄相关变化。通过诱导这一发育序列的改变，本研究试图提供阿片受体系统与纳洛酮诱导的厌食症之间的关联。对孕期接受吗啡（7.5毫克/千克，每日两次，皮下注射）或生理盐水治疗的母亲的后代，以及出生后第1 - 5天皮下注射吗啡（5毫克/千克）、纳曲酮（10毫克/千克）或生理盐水的未治疗母亲的婴儿，在第10、12和14天进行测试，以检测急性剂量纳洛酮（1或5毫克/千克，腹腔注射）后剥夺诱导的乳汁消耗情况。纳洛酮减少了出生后长期接受吗啡治疗的10日龄和12日龄婴儿的食物摄入量。在14日龄时，纳洛酮减少了所有预处理组的食物摄入量，且吗啡预处理改变了纳洛酮诱导的喂养调节的剂量反应曲线。纳洛酮对孕期接受吗啡或生理盐水治疗的母亲的10日龄或12日龄后代，或对出生后长期接受纳曲酮或生理盐水预处理的那些年龄组的食物摄入量没有影响。观察到的这些变化发生在没有明显畸形、戒断症状和活动差异的情况下。这些结果表明阿片受体可能参与进食。
