Aroyewun O, Barr G A
Neuropharmacology. 1982 Aug;21(8):757-62. doi: 10.1016/0028-3908(82)90061-2.
The observation that acute administration of opiate agonists to rodent adults increased food intake while the reverse was true with a single injection of an opiate antagonist has led to the suggestion that endogenous opioids may in part mediate feeding behaviour in adult rodents. Studies were performed in infant rats to explore further the generality and ontogeny of this function. In three models of food availability, the effects of naloxone and naltrexone were assessed in deprivation-induced feeding tests in 3-, 10-, 12, 14- and 19-day-old preweanling rats. Naloxone or naltrexone attenuated food intake only after 14 days. Functional immaturity of the opioid systems vis-a-vis ingestive behaviour may account for this developmental sequence.
给成年啮齿动物急性注射阿片类激动剂会增加食物摄入量，而单次注射阿片类拮抗剂则会产生相反的效果，这一观察结果表明内源性阿片类物质可能在一定程度上介导成年啮齿动物的摄食行为。在幼鼠中进行了研究，以进一步探索该功能的普遍性和个体发生情况。在三种食物供应模式下，在3日龄、10日龄、12日龄、14日龄和19日龄的断奶前大鼠的剥夺诱导摄食试验中评估了纳洛酮和纳曲酮的作用。纳洛酮或纳曲酮仅在14天后才会减少食物摄入量。阿片系统相对于摄食行为的功能不成熟可能解释了这一发育顺序。
