Tian Hu S, Brändle E, Zbinden G
Pharmacology. 1983;26(4):210-20. doi: 10.1159/000137804.
Cardiotoxicity of doxorubicin, 2 mg/kg i.p. twice weekly in rats, was assessed by serial electrocardiography and electron microscopy. The toxic effects were markedly inhibited by ICRF-159, 50 mg/kg p.o. given 1 h before doxorubicin. The development of nephropathy characterized by proteinuria, hyperlipidemia and glomerular and tubular changes was significantly retarded, and the degenerative changes of peripheral nerves were markedly reduced. On the other hand, ICRF-159 enhanced the depressant effects of doxorubicin on bone marrow function. Doxorubicin reduced body weight gain, caused ascites, decrease in heart and thymus weight, and increase in liver and kidney weight. These changes were also inhibited or attenuated by ICRF-159 pretreatment.
通过连续心电图和电子显微镜评估阿霉素（每周两次腹腔注射2mg/kg，用于大鼠）的心脏毒性。在阿霉素给药前1小时口服给予50mg/kg的ICRF-159可显著抑制毒性作用。以蛋白尿、高脂血症以及肾小球和肾小管变化为特征的肾病发展显著延迟，外周神经的退行性变化也明显减少。另一方面，ICRF-159增强了阿霉素对骨髓功能的抑制作用。阿霉素使体重增加减少，导致腹水、心脏和胸腺重量减轻以及肝脏和肾脏重量增加。这些变化也因ICRF-159预处理而受到抑制或减轻。
