DNA甲基化在衰老过程中会减少，但在永生化细胞中不会。
DNA methylation decreases in aging but not in immortal cells.
作者信息
Wilson V L, Jones P A
出版信息
Science. 1983 Jun 3;220(4601):1055-7. doi: 10.1126/science.6844925.
PMID:6844925
Abstract
When normal diploid fibroblasts from mice, hamsters, and humans were grown in culture, the 5-methylcytosine content of their DNA's markedly decreased. The greatest rate of loss of 5-methylcytosine residues was observed in mouse cells, which survived the least number of division. Immortal mouse cell lines had more stable rates of methylation.
摘要
当来自小鼠、仓鼠和人类的正常二倍体成纤维细胞在培养中生长时，其DNA中的5-甲基胞嘧啶含量显著下降。在小鼠细胞中观察到5-甲基胞嘧啶残基的最大丢失率，这些细胞存活的分裂次数最少。永生小鼠细胞系具有更稳定的甲基化率。
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