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光和激动剂可改变血管活性肠肽对松果体N-乙酰基转移酶的诱导作用。

Light and agonists alter pineal N-acetyltransferase induction by vasoactive intestinal polypeptide.

作者信息

Yuwiler A

出版信息

Science. 1983 Jun 3;220(4601):1082-3. doi: 10.1126/science.6844931.

DOI:10.1126/science.6844931
PMID:6844931
Abstract

Vasoactive intestinal polypeptide stimulated serotonin N-acetyltransferase activity in rat pineal glands in organ culture by a postsynaptic action that was independent of the beta-receptor. The magnitude of stimulation could be altered by environmental lighting conditions and by prior exposure to the agonist. Such up- and down-regulation, well known for catecholaminergic stimulation of this system, is compatible with a possible control of the pineal by vasoactive intestinal polypeptide as well as by catecholamines.

摘要

血管活性肠肽通过一种独立于β受体的突触后作用，刺激器官培养的大鼠松果体中的血清素N-乙酰转移酶活性。刺激的程度可因环境光照条件以及先前暴露于激动剂而改变。这种上调和下调现象，在该系统的儿茶酚胺能刺激中是众所周知的，这与血管活性肠肽以及儿茶酚胺对松果体的可能调控是一致的。

相似文献

1
Light and agonists alter pineal N-acetyltransferase induction by vasoactive intestinal polypeptide.光和激动剂可改变血管活性肠肽对松果体N-乙酰基转移酶的诱导作用。
Science. 1983 Jun 3;220(4601):1082-3. doi: 10.1126/science.6844931.
2
Vasoactive intestinal peptide stimulation of pineal serotonin-N-acetyltransferase activity: general characteristics.
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Vasoactive intestinal peptide stimulates type II thyroxine 5'-deiodinase and N-acetyltransferase activities in dispersed pineal cells of euthyroid and hypothyroid rats.血管活性肠肽刺激正常甲状腺和甲状腺功能减退大鼠的松果体分散细胞中的II型甲状腺素5'-脱碘酶和N-乙酰转移酶活性。
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Commonalities in vasoactive intestinal peptide and peptide N-terminal histidine C-terminal isoleucine stimulation of N-acetyltransferase activity in the rat pineal.
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Does maximal serotonin N-acetyltransferase activity necessarily reflect maximal melatonin production in the rat pineal gland?
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Comparison of the effects of beta-adrenergic agents on pineal serotonin N-acetyltransferase activity and melatonin content in two species of hamsters.β-肾上腺素能药物对两种仓鼠松果体血清素N-乙酰基转移酶活性和褪黑素含量影响的比较
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Prenatal alcohol exposure and pineal response to isoproterenol, vasoactive intestinal polypeptide, and desmethylimipramine.产前酒精暴露与松果体对异丙肾上腺素、血管活性肠肽和去甲丙咪嗪的反应。
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Sympathetic regulation of circadian rhythm of serotonin N-acetyltransferase activity in pineal gland of infant rat.幼鼠松果体中血清素N-乙酰基转移酶活性昼夜节律的交感神经调节
J Neurochem. 1982 Mar;38(3):797-802. doi: 10.1111/j.1471-4159.1982.tb08700.x.

引用本文的文献

1
Vasoactive intestinal polypeptide (VIP)-containing neurons: distribution throughout the brain of the chick (Gallus domesticus) with focus upon the lateral septal organ.含血管活性肠肽（VIP）的神经元：在鸡（家鸡）脑内的分布，重点关注外侧隔器官。
Cell Tissue Res. 1994 Jan;275(1):91-107. doi: 10.1007/BF00305378.
2
Immunohistochemical localization of vasoactive intestinal peptide (VIP) in the circumventricular organs of the rat.血管活性肠肽（VIP）在大鼠室周器官中的免疫组织化学定位。
Cell Tissue Res. 1989 Feb;255(2):307-13. doi: 10.1007/BF00224113.
3
Vasoactive intestinal peptide stimulates melatonin release from perifused pineal glands of rats.
J Neural Transm Gen Sect. 1990;79(1-2):69-79. doi: 10.1007/BF01251002.
4
In vitro effects of putative neurotransmitters on synaptic ribbon numbers and N-acetyltransferase activity in the rat pineal gland.假定神经递质对大鼠松果体突触带数量和N - 乙酰转移酶活性的体外作用。
J Neural Transm Gen Sect. 1992;89(3):167-78. doi: 10.1007/BF01250669.